مقالات

افراد مبتلا به زوال عقل علاوه بر انباشته شدن پروتئین های نادرست، نورون‌های آسیب دیده نیز دارند.
بافت مغز را می توان به دو قسمت سفید و خاکستری طبقه بندی کرد. ماده خاکستری از بدنه سلولی نورون ها تشکیل شده است، در حالی که ماده سفید از آکسون هایی تشکیل شده است که اطلاعات را منتقل می کنند.
تعدادی از فرآیندهای آکسونی در ماده سفید در یک لایه عایق به نام غلاف میلین قرار دارند. غلاف میلین به ماده سفید رنگ می دهد و به آکسون ها اجازه می دهد تا تکانه های الکتریکی را سریعتر و کارآمدتر هدایت کنند.
افراد مبتلا به زوال عقل و اختلال شناختی خفیف، دارای ناهنجاری هایی در ماده سفید خود هستند. برخی از این ناهنجاری‌های ماده سفید، مانند افزایش حجم ماده سفید و کاهش یکپارچگی دستگاه ماده سفید، همچنین نشانگر بیماری‌های عروق مغزی هستند.
حجم زیاد ماده سفید با استفاده از MRI ​​شناسایی می‌شوند و نشان دهنده ضایعات ماده سفید هستند که عموماً در اثر بیماری عروق کوچک مغزی ایجاد می‌شوند.
یکپارچگی دستگاه ماده سفید بر حسب ناهمسانگردی کسری با استفاده از تکنیکی به نام تصویربرداری تانسور انتشار اندازه گیری می شود. این ناهنجاری های ماده سفید به دلیل آسیب به رگ های خونی ممکن است به زوال شناختی کمک کند.a

Association Study Of HLA-DQB1*0602 Allele In Iranian Patients With Narcolepsy

Geremew D1, Rahimi-Golkhandan A2, Sadeghniiat-Haghighi K2, Shakiba Y3, Khajeh-Mehrizi A4, Ansaripour B5, Izad M5. Abstract Narcolepsy is a rare, disabling disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucinations and sleep paralysis. Several studies demonstrated its association with HLA-DQB1*0602 in various ethnic groups. Our study aimed to determine the prevalence of HLA-DQB1*0602 allele in Iranian patients …

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Efficacy Of A Combination Of Melissa Officinalis L. And Nepeta Menthoides Boiss. & Buhse On Insomnia: A Triple-Blind, Randomized Placebo-Controlled Clinical Trial

J Altern Complement Med. 2018 May 9. doi: 10.1089/acm.2017.0153. [Epub ahead of print] Ranjbar M1,2, Salehi A2, Rezaeizadeh H3, Zarshenas MM4,5, Sadeghniiat-Haghighi K6, Mirabzadeh M7, Firoozabadi A2,8. Abstract BACKGROUND: Insomnia is a prevalent sleep disorder that has not been well managed thus far. There are numerous medicaments for treatment of …

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Obstructive Sleep Apnea And Severity Of Coronary Artery Disease

Caspian J Intern Med. 2018 Summer;9(3):276-282. doi: 10.22088/cjim.9.3.276. Vasheghani-Farahani A1, Kazemnejad F2, Sadeghniiat-Haghighi K3, Saadat S4, Tavakolipoor P5, Yazdani T5, Alidoosti M2, Ghasem-Amooeian V2, Ashraf H1. Abstract BACKGROUND: It has been implicated that obstructive sleep apnea (OSA) is associated with increased risk of cardiovascular disease including stroke, myocardial infarction, coronary …

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Investigating The Prevalence Of Sleep Disorder And The Impact Of Sweet Almond On The Quality Of Sleep In Students Of Tehran, Iran

Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran ABSTRACT Insomnia is an important problem in medical sciences students and has implications for their educational progress. The current study aimed to estimate the prevalence …

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Bedroom Design Orientation And Sleep Electroencephalography Signals

Authors: Amin Hekmatmanesh, Maryam Banaei, Khosro Sadeghniiat Haghighi, Arezu Najafi Publication date: 2019/1/1 Journal: Acta Medica International Background: Orientation is a significant factor in architectural design that may affect well-being. Body direction does not change during sleeping, and sleeping is sensitive and affected by environmental factors. Aims: This neuroarchitecture study aimed to …

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Bedroom Design Orientation And Sleep Electroencephalography Signals

Authors: Amin Hekmatmanesh, Maryam Banaei, Khosro Sadeghniiat Haghighi, Arezu Najafi Publication date: 2019/1/1 Journal: Acta Medica International Background: Orientation is a significant factor in architectural design that may affect well-being. Body direction does not change during sleeping, and sleeping is sensitive and affected by environmental factors. Aims: This neuroarchitecture study aimed to …

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Sleep Breathing Disorders: DEVELOPMENT OF AN OBJECTIVE TOOL FOR PREDICTING OBSTRUCTIVE SLEEP APNEA AMONG ADULTS: PAN APNEA Index

K. Sadeghniiat-Haghighi, E. Afzalinejad, A. Najafi, Z.B. Alemohammad, S. Akbarpour Occupational Sleep Research Center Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of In this study, we considered only objective parameters to predict OSA which enhances reliability for diagnosis especially in occupational settings. Introduction: Obstructive sleep apnea …

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Sleep Breathing Disorders: INSOMNIA SEVERITY AND DEPRESSION AMONG PATIENTS WITH OBSTRUCTIVE SLEEP APNEA

K. Sadeghniiat-Haghighi1, A. Najafi, A. Rahimi-Golkhandan, S. Akbarpour, M. Mohammadzade Occupational Sleep Research Center, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of Introduction: Obstructive Sleep Apnea (OSA) and Insomnia are two common sleep disorders. More than 40% of patients with OSA reported at least one insomnia …

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Sleep Breathing Disorders: CONTINUOUS POSITIVE AIRWAY PRESSURE ADHERENCE IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME

A. Najafi, N. Naeimabadi, K. Sadeghniiat-Haghighi, M. Salmani-Nodoushan, A. RahimiGolkhandan Occupational Sleep Research Center, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Department of Occupational medicine, Industrial Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of Introduction: Obstructive sleep apnea syndrome …

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GCH1 (Rs841) Polymorphism In The Nitric Oxide-Forming Pathway Has Protective Effects On Obstructive Sleep Apnea

Samaneh Sheikhi Kouhsar, Mohammadreza Bigdeli, Yadollah Shakiba, Khosro Sadeghniiat Abstract Several studies have recently investigated the contribution of genetic factors in obstructive sleep apnea (OSA). Patients with OSA suffer from a reduction in nitric oxide (NO) serum level. This study investigated rs841, A930G p22phox, and rs1799983 polymorphisms in three critical …

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